United States securities and exchange commission logo April 25, 2024 Jodie Morrison Chief Executive Officer Q32 Bio Inc. 830 Winter Street Waltham, MA 02451 Re: Q32 Bio Inc. Registration Statement on Form S-1 Filed April 19, 2024 File No. 333-278829 Dear Jodie Morrison: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Daniel Crawford at 202-551-7767 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Sarah Ashfaq, Esq.